Alternative source for anti-cancer drug identified
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Researchers on the Indian Institute of Technology-Madras have identified a sustainable, high-yielding various source for the anti-cancer drug camptothecin.
Camptothecin is an alkaloid remoted from ‘Camptotheca Acuminata’, a Chinese tree and ‘Nothapodytes Nimmoniana’, an Indian tree. It requires almost 1,000 tonnes of plant materials to extract one tonne of camptothecin. In the previous decade, the inhabitants of N. Nimmoniana fell by 20%, in line with the researchers.
The researchers have developed a microbial fermentation course of that may be an economically-efficient technique of manufacturing to fulfil the market demand.
Two medication, topotecan and irinotecan, are produced utilizing camptothecin.
Over a dozen derivatives of camptothecin are underneath varied levels of scientific trials.
Smita Srivastava, affiliate professor within the Department of Biotechnology, led the analysis.
Ms. Srivastava, the principal investigator of the research mentioned, “The novelty of the work lies in the fact that unlike other potential microbial strains reported, this strain has been found to show sustainable production even beyond 100 generations. The plan now is to use the isolated novel strain to develop a microbial fermentation-based sustainable bioprocess for large-scale in vitro production of camptothecin, preferably in collaboration with interested industrial partners,” she mentioned.
There are 5 members on her group, together with a researcher from the University of Agricultural Sciences, GKVK, Bengaluru.
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