Malayali researcher to study gender connection of Alzheimer’s
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She receives Canadian post-doctoral fellowship to probe position of G-protein-coupled receptors
After a current discovering by the Cleveland Clinic indicated that the COVID-19 an infection has a relationship with circumstances corresponding to mind irritation that occurs in Alzheimer’s illness, analysis on the mode of pathogenesis in Alzheimer’s is gaining important consideration.
A Malayali researcher’s work on this path is being inspired by the University of Ottawa. Shaarika Sarasija was lately awarded a three-year Canadian Institute of Health Research post-doctoral fellowship to study the position of G-protein-coupled receptors in Alzheimer’s illness.
Having joined the lab of Dr. Stephen S.G. Ferguson on the University of Ottawa, she plans to additionally discover out why ladies seem to be extra vulnerable to Alzheimer’s illness. Hailing from Thiruvananthapuram, Shaarika Sarasija is the daughter of Malayalam movie producer Kireedom Unni.
“The number of women showing Alzheimer’s symptoms is twice the number of men,” she says. “The major risk factor for Alzheimer’s disease is age and therefore, the increased incidence of the disease in women was initially thought to be a consequence of their longer lifespan. Current research, however, showed that this propensity for Alzheimer’s disease in women is seen even when matched for age and lifestyle of men. This could be due to intrinsic biological differences in men and women, including hormonal changes, sexual dimorphism in brain anatomy, metabolic functions, and stress.”
She graduated with a PhD in Biomedical Sciences in 2017 for her work finding out the non-amyloidogenic position of presenilin in Alzheimer’s illness etiology, within the lab of Dr Kenneth R. Norman on the Albany Medical College.
“As the most common form of dementia, Alzheimer’s disease ravages a large population of the world’s elderly but, despite decades of research, the cause of the disease remains elusive. A common hallmark of this disease is the presence of misfolded proteins called amyloid plaques,” she says.
“My research showed that neurodegeneration can occur in the absence of amyloid plaques due to aberrant calcium signalling and subsequent mitochondrial calcium, oxidative stress, and dysregulated autophagy,” she provides.
This work has been printed in journals corresponding to Genetics, eLife and Aging Cell and offered at varied worldwide conferences.
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